Older Patients Eligible For Surgery Can Benefit From Lung Cancer Screening Programs

Older individuals betwixt nan ages of 75 and 80 who are eligible for lung room whitethorn execute endurance outcomes comparable to younger patients pursuing lung crab screening, according to investigation presented coming astatine nan International Association for nan Study of Lung Cancer (IASLC) 2025 World Conference connected Lung Cancer (WCLC).

Despite half of lung cancers being diagnosed successful group aged 75 aliases older, randomized grounds connected screening outcomes successful this property group is limited. Most nationalist lung crab screening programs, including nan UK's, extremity astatine property 74. The U.S. Preventive Services Task Force recommends screening up to property 80, though small was known astir really overmuch use is achieved by extending nan precocious property limit to 80. This study compared outcomes betwixt patients aged 55–74 and those aged 75–80 diagnosed pinch screen-detected lung crab successful 2 UK targeted lung crab screening programs.

The Yorkshire Lung Screening Trial (YLST) and nan North & East Manchester Lung Health Check (NEM-LHC) programme systematically invited group pinch a history of smoking opening successful 2019. Researchers analyzed objective information from 574 invasive lung crab cases, of which 190 (33%) were successful nan 75–80 property group. Stage distribution was akin betwixt property groups.

Curative-intent curen rates were precocious wide (87%), but surgical resection rates were little successful nan older group (42% vs. 58%, p<0.001). All-cause mortality was higher among those aged 75–80 (HR 1.54, 95% CI 1.12–2.10), pinch mortality astatine 4 years being 44% versus 34%. However, successful patients treated pinch surgery, endurance rates were comparable betwixt property groups (16% vs. 18% mortality astatine 4 years; HR 1.00).

Our findings propose that extending lung crab screening up to property 80 could beryllium valuable for older adults who are fresh for surgery. Screening action incorporating surgical fitness, alternatively than property alone, whitethorn let america to present curative curen to much people pinch lung cancer."

Patrick Goodley, Manchester University NHS Foundation Trust, United Kingdom