Genomic Testing Speeds Patient Accrual In High-risk Prostate Cancer Trial

The NRG Oncology NRG-GU009 (PREDICT-RT) study evaluating intensified and de-intensified concurrent radiation regimens based connected nan genomic consequence of patients pinch high-risk prostate crab completed accrual and met its accrual milestone of 2,478 patients astir 2 years earlier than nan trial's anticipated accrual completion date.

The incidence of men receiving high-risk prostate crab diagnoses is connected nan summation successful caller years. The PREDICT-RT study was designed to amended value of life and outcomes for these patients while tailoring treatments to meet each individual's needs based connected their Decipher Prostate Genomic Classifier scores which usage nan tumor's genomic accusation to foretell aggressiveness."

Paul Nguyen, MD MBA, Mass General Brigham

Paul Nguyen is besides associated pinch the Dana Farber Cancer Centers and nan Principal Investigator of nan PREDICT-RT study.

The PREDICT-RT study stratifies enrolled patients pinch high-risk crab by Decipher Risk Score. Decipher testing was conducted by Veracyte, Inc. (VCYT), a world diagnostics institution that provides high-performing crab genomic testing and besides participates extensively successful objective investigation astir prostate cancer. The Decipher Risk Score was utilized to find if a diligent should beryllium assigned to nan de-intensification cohort aliases nan intensification cohort.

Patients pinch a Decipher people of little than aliases adjacent to 0.85 were assigned to nan De-Intensification study. Patients connected nan De-Intensification study were stratified by Decipher people range, boost type, anterior pelvic treatment, and ACE-27 comorbidity. Following stratification, patients connected nan De-intensification study were randomly assigned to curen limb 1 aliases limb 2. Patients connected curen limb 1 received nan modular of attraction for this type of crab which includes radiotherapy (RT) and 24 months of androgen deprivation therapy (ADT). Patients connected curen limb 2 received RT and 12 months of ADT.

Patients pinch a Decipher people greater than 0.85 aliases node affirmative illness were assigned to nan Intensification study. Patients connected nan Intensification study were stratified by boost type, anterior pelvic treatment, and nodal status. Following stratification, patients connected nan Intensification study were randomly assigned to curen limb 3 aliases limb 4. Patients connected curen limb 3 received nan modular of attraction RT pinch 24 months of ADT, whereas patients connected curen limb 4 received RT, 24 months of ADT, and 24 months of apalutamide.

The superior nonsubjective of nan De-intensification study is to find if men pinch high-risk prostate crab successful a little Decipher people scope tin beryllium treated pinch little ADT and execute metastasis-free endurance results not worse than modular ADT. The superior nonsubjective of nan Intensification study is to find if nan summation of apalutamide to nan modular of attraction tin thief amended metastasis-free endurance for men pinch high-risk prostate crab successful a higher Decipher people range.

"Our study squad would for illustration to convey our sites and our patients who quickly enrolled to this very important trial. We look guardant to reporting nan results arsenic information becomes disposable from this trial," added Oliver Sartor, MD, of East Jefferson General Hospital and nan co-Principal Investigator of nan PREDICT-RT study.