Evening Meals Hold The Key To Morning Glucose Control In Prediabetes

The measurement glucose is regulated astatine nighttime plays a cardinal domiciled successful fasting glucose levels nan adjacent morning, erstwhile humor sweetener is expected to beryllium astatine its lowest. This parameter is peculiarly important successful group pinch dysglycemia, which is characterized by abnormal glucose levels. However, small investigation has been done successful this area. Now, a study involving nan Universitat Oberta de Catalunya (UOC) has shown that nan past repast of nan time plays a important portion successful regulating glucose levels nan pursuing morning, a facet that tin beryllium particularly captious for group pinch prediabetes and whitethorn beryllium decisive successful preventing nan onset of this chronic disease.

According to nan World Atlas of Diabetes, Spain has 1 of nan highest rates of glucosuria successful Europe, ranking 5th overall. It affects 14% of nan organization - complete 5 cardinal group - and costs nan wellness strategy much than €14 cardinal each year.

The study, Biological vs. Chronological Overnight Fasting: Influence of Last Evening Meal connected Morning Glucose successful Dysglycemia, published arsenic unfastened entree in Nutrients, analyses nan domiciled of fasting glucose levels aft nan past repast of nan day, showing that carbohydrate depletion and nan individual's sensitivity to insulin some person an impact. This find whitethorn person implications for nan dietary recommendations fixed to individuals pinch prediabetes to forestall them from processing nan disease.

"Recommendations regarding nan intake of carbohydrates and calories successful nan past evening repast could beryllium tailored successful statement pinch nan patient's insulin sensitivity. And humor glucose levels aft this repast (postprandial glycemic response) could beryllium monitored truthful that dietary aliases pharmacological treatments tin beryllium adjusted. This would let for more personalized and adaptive humor glucose management," said Diana Díaz-Rizzolo, teacher successful nan UOC's Faculty of Health Sciences and a personnel of nan Nutrition, Food, Health and Sustainability (NUTRALiSS) research group, affiliated to the Digital Health, Health and Well-being Research Unit. Díaz-Rizzolo is besides a postdoctoral interrogator astatine Columbia University, which took portion successful nan study. 

Meal times and chronotypes besides matter

The study, conducted by nan UOC successful collaboration pinch investigation institutions successful nan US, analysed 33 men and women aged 50 to 75 who were overweight aliases obese and had prediabetes, meaning their humor glucose levels were higher than normal but not yet successful nan diabetic range. After a time pinch a controlled fare and repast times, their glucose levels were measured nan adjacent greeting pursuing a 10-hour overnight fast. Patients wore a continuous glucose show to perpetually power their humor sweetener levels.

The results of nan investigation show that dietary recommendations should see not only nan amount of carbohydrates patients tin consume, arsenic is usually nan case, but besides the timing of nan past evening meal. The later nan meal, nan harder it becomes to modulate glucose, arsenic nan researchers had antecedently shown, while its nutritional contented remains important for controlling overnight glucose levels. The researchers besides recovered that an individual's insulin sensitivity influences glucose regulation. 

Díaz-Rizzolo believes that our chronotype – whether we are greeting aliases evening group – tin besides play an important role: "Our soul biologic timepiece could play a cardinal domiciled successful overnight glucose metabolism and fasting glucose levels. This accusation could beryllium captious for making much personalized recommendations, taking into relationship not only insulin sensitivity, but besides each individual's circadian floor plan (morning versus evening people). Understanding really chronotype and glycemic consequence interact could make glucosuria prevention and guidance strategies much precise," she explained.

Díaz-Rizzolo argues that dietary recommendations for patients pinch prediabetes aliases insulin guidance should beryllium based on:

- Controlling nan creation and glycemic load of nan past repast of nan day, avoiding an excessive magnitude of carbohydrates.

- Adjusting nan magnitude of carbohydrates according to nan individual's insulin sensitivity, arsenic patients pinch little sensitivity whitethorn person a worse glycemic response.

- Considering nan timing of meals to debar nighttime glycemic spikes that tin interfere pinch metabolism and fasting glucose.

New technologies: a turning constituent successful glucosuria management

Continuous glucose monitors, mobile apps to way our diets and artificial intelligence platforms that let much elaborate and real-time monitoring of glucose are changing nan measurement patients negociate their diabetes.

These tools, tin greatly amended patients' value of life and metabolic control. They thief to observe glycemic imbalances early, allowing diet, medicine and beingness activity to beryllium adjusted according to nonsubjective data. And they alteration patients to participate actively successful their curen connected an informed basis."

Diana Díaz-Rizzolo, lecturer, UOC's Faculty of Health Sciences

Díaz-Rizzolo and colleagues from nan earlier study person precocious presented a new methodology that uses artificial intelligence algorithms to automatically and reliably measurement nan existent clip spent fasting, what's known arsenic nan biologic overnight accelerated (BOF). This innovative method, presented astatine nan American Diabetes Association Congress successful Chicago, shows really overnight fasting impacts humor sweetener levels successful patients pinch prediabetes and type 2 diabetes. 

"Combining nan usage of continuous glucose monitors pinch these algorithms tin thief group cognize really nan clip aliases type of repast they eat successful nan evening determines their glucose levels, together pinch nan BOF, which could beryllium a marker of metabolic health," Díaz-Rizzolo said. These devices will besides make it imaginable to place metabolic subtypes and postprandial consequence patterns, thing accepted methods cannot achieve, thereby enabling much personalized curen based connected a deeper knowing of each patient's metabolism. 

"The world of artificial intelligence successful medicine is opening doors that we could ne'er person imagined. In metabolic diseases, it tin thief america make early predictions of nan consequence of processing glucosuria and complications. It tin besides beryllium useful for jointly analysing familial and epigenetic consequence factors, metabolomics and nan creation of nan intestinal microbiota, which will thief america to tailor treatments moreover further," she explained.