Age Influences Amyloid Positivity In Parkinson's Disease Without Dementia

A caller investigation insubstantial was published in Volume 17, Issue 8 of Aging-US on August 6, 2025, titled "Age-related trends successful amyloid positivity successful Parkinson's illness without dementia."

In this study, led by first writer Keiko Hatano and corresponding writer Masashi Kameyama from the Tokyo Metropolitan Institute for Geriatrics and Gerontology in Japan, researchers recovered that patients pinch Parkinson's illness (PD) diagnosed successful their 80s showed a importantly higher complaint of amyloid positivity-an parameter associated pinch Alzheimer's disease-compared to those diagnosed astatine a younger age. Importantly, nary of nan participants had dementia. These findings propose that older patients pinch PD whitethorn look a greater consequence of early cognitive diminution and could use from early screening for Alzheimer's-related encephalon changes.

Amyloid-beta is considered a cardinal marker of cognitive decline. While it is known that amyloid accumulation contributes to PD pinch dementia, its domiciled successful patients who person not developed cognitive problems remains little understood. This study aimed to research really property influences amyloid buildup successful group pinch PD who do not yet show signs of dementia.

The researchers analyzed information from 89 individuals pinch PD and nary signs of dementia. Participants were divided into 2 age-based groups: those diagnosed earlier property 73 (LOW group) and those diagnosed astatine property 73 aliases older (HIGH group). Using cerebrospinal fluid samples, they measured levels of amyloid-beta, a modular method for detecting early Alzheimer's-related changes. The findings revealed that 30.6% of nan older group tested affirmative for amyloid, compared to conscionable 10.0% successful nan younger group.

"[…] we elucidated nan prevalence of amyloid positivity successful patients pinch PD without dementia, whose mean property astatine test was 80.2 years, utilizing CSF Aβ42 levels."

Interestingly, some property groups of Parkinson's patients had a little complaint of amyloid positivity than cognitively normal individuals of nan aforesaid property successful nan wide population. This unexpected consequence suggests that PD whitethorn change really amyloid accumulates successful nan brain, perchance shortening nan shape successful which amyloid builds up silently earlier symptoms appear. The authors propose that amyloid buildup could accelerate nan modulation from patient cognition to dementia successful patients pinch PD. The study besides observed age-related associations pinch different biologic markers of Alzheimer's disease, specified arsenic tau macromolecule levels. 

As nan world organization continues to property and nan number of older adults diagnosed pinch PD grows, identifying early informing signs of cognitive diminution becomes progressively important. These findings whitethorn thief pass early screening approaches and support nan improvement of therapies aimed astatine delaying aliases preventing dementia successful group pinch Parkinson's disease.