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2 months ago
Pancreatic crab is 1 of nan astir fierce crab types. A caller study from Karolinska Institutet, successful collaboration pinch nan Department of Pathology astatine Karolinska University Hospital, shows that tumor cells turn not only successful nan connective tissue-rich situation emblematic of nan disease, but besides successful damaged parts of nan pancreas wherever normal insubstantial is altered. The findings whitethorn supply caller insights into tumor improvement and treatment.
Pancreatic crab is an fierce disease, and dissimilar galore different cancers, endurance rates person hardly improved. Researchers astatine Karolinska Institutet person now shown that pancreatic tumor cells not only dispersed successful nan connective tissue-rich situation that is simply a well-known characteristic of pancreatic crab but besides turn into damaged parts of normal pancreatic tissue. There, nan crab tin create its ain environment.
The study, published successful Nature Communications, is based connected samples from 108 patients who underwent room astatine Karolinska University Hospital. In almost each cancers, tumor cells were recovered successful nan insubstantial that produces digestive enzymes, but is damaged erstwhile tumor cells turn into it.
"We spot that nan tumor cells accommodate to nan situation they find themselves in. In damaged areas of normal pancreatic tissue, they grounds different characteristics than successful nan connective tissue-rich portion of nan tumor," says Marco Gerling, a interrogator astatine nan Department of Clinical Science, Intervention and Technology, Karolinska Institutet, who led nan study together pinch pathologist Carlos Fernández Moro.
May impact curen response
The researchers besides observed that tumor cells successful nan damaged areas much often had a alleged "classical" tumor profile, while cells successful nan connective tissue-rich portion had a much fierce profile. The damaged areas contained support cells that definitive a circumstantial protein, NGFR, which has antecedently been linked to nan treatment process of damaged tissue.
This type of damaged insubstantial whitethorn play a domiciled successful really nan tumor develops and responds to treatment."
Marco Gerling, interrogator astatine nan Department of Clinical Science, Intervention and Technology, Karolinska Institutet
The study was done successful collaboration pinch doctors astatine Karolinska University Hospital and researchers astatine Uppsala University, SciLifeLab, and nan University of Bergen. It has been funded by nan Swedish Research Council, nan Swedish Cancer Society, nan Swedish Society for Medical Research, and Region Stockholm, among others.
Source:
Journal reference:
Söderqvist, S., et al. (2025). An injury-associated lobular microniche is associated pinch nan classical tumor compartment phenotype successful pancreatic cancer. Nature Communications. doi.org/10.1038/s41467-025-63864-7
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