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Southwest Research Institute (SwRI) has demonstrated a caller exertion for its cell-expansion bioreactor to beforehand insubstantial engineering and cell-based therapies for curen of injuries and diseases.
SwRI scientists utilized nan bioreactor to replicate induced Pluripotent Stem Cells (iPSCs) derived from big skin, blood, and different somatic cells. Their pluripotent authorities allows iPSCs to differentiate into immoderate different compartment type successful nan body, overmuch for illustration embryonic stem cells but without nan aforesaid ethical ambiguity. Large quantities of iPSCs are needed for regenerative medicine and individualized healthcare, but existent exertion requires manual production.
Using nan SwRI-developed single-use 3D-printed bioreactor, we successfully harvested important quantities of iPSCs. We are moving connected further differentiating those iPSCs into neural progenitor cells, which could support nan regeneration of neurons that are damaged owed to injury. International studies person shown that neural progenitor cells tin repair nan spinal cord erstwhile administered successful nan first 28 days pursuing a spinal cord injury."
Dr. Nick Mc Mahon, Senior Research Scientist, leader connected nan project
SwRI's 3D printed bioreactor matrix boasts a larger surface-to-volume ratio compared to accepted 2D compartment civilization devices specified arsenic flasks aliases dishes, and it tin turn much cells utilizing an automated perfusion method. Due to nan exceptional geometry of SwRI's bioreactor, cells support a monolayer without forming clusters during nan cultivation process, minimizing nan consequence of spontaneous differentiation into nan incorrect type of cells.
"Since nan find of iPSCs successful nan early 2000s, scientists person been exploring their imaginable to revolutionize medicine by utilizing a patient's ain cells to repair aliases switch damaged tissues to debar immune rejection. Unlike embryonic stem cells, iPSCs airs nary ethical controversy, making them a promising and responsible way toward personalized medicine," said Institute Engineer Dr. Jian Ling.
SwRI plans to further refine nan prototype to beforehand automation and supply a simplified plug-and-play compartment replication level to accelerate nan improvement of iPSC-based therapies.
This project received backing done SwRI's Internal Research and Development Program. In 2024, SwRI invested much than $11 cardinal successful tomorrow's exertion to broaden its knowledge base, grow its estimation arsenic a leader successful subject and exertion and promote its staff's master development. To study more, visit: Southwest Research Institute Internal R&D.
SwRI's Pharmaceutical and Bioengineering Department advances caller pharmaceutical research, civilization assays and biomedical devices. SwRI unit will coming astatine nan American Association of Pharmaceutical Scientists (AAPS) PharmSci 360 November 9-12 successful San Antonio.
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