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2 months ago
Southwest Research Institute (SwRI) and The University of Texas astatine San Antonio (UT San Antonio) are advancing a smart biosensor coating to streamline nan accumulation of immunotherapies for crab treatments. Researchers scheme to usage caller biosensor coatings to alteration automated processes and trim quality errors and costs associated pinch their production.
Quartz Crystal Microbalances (QCM) person been astir since nan mid-20th century, and they usability by detecting wide changes connected a surface. We initially adapted QCM exertion during nan pandemic to observe viruses. We're now processing a caller smart coating to alteration a wholly closed-loop process for continuous monitoring and characterization of cells during nan accumulation of immunotherapies, which should importantly trim accumulation costs."
Carlos M. Cantu, co-investigator connected nan project, SwRI Research Engineer
To pat into nan immune system's analyzable earthy defenses, scientists tin reprogram T lymphocytes, aliases T-cells, to onslaught crab cells. A sub-type of achromatic humor cells, T-cells defender nan assemblage against pathogens. By genetically engineering T-cells into chimeric antigen receptor T-cells (CAR T-cells), doctors tin target a patient's circumstantial crab utilizing their ain humor cells. However, producing these personalized immunotherapies tin costs betwixt $300,000-$1 cardinal for a azygous patient. Limitations successful existing travel cytometry, nan existent method for CAR-T compartment manufacturing, requires trained personnel, costly instrumentality that lacks in-process real-time control, and manual labeling pinch antibodies to guarantee that each different types of achromatic humor cells and cancerous cells are filtered retired during CAR T-cell production, arsenic good arsenic determination of generated CAR T-cells from T-cell starting material.
The SwRI and UT San Antonio investigation teams are moving to guarantee nan caller biosensor coating will reside barriers for wider accessibility of immunotherapies. The squad plans to merge their biosensor coating pinch existing technologies and bioreactors utilized to propagate CAR T-cells.
"We dream our sensor coatings will beforehand nan CAR T-cell therapy ecosystem and that nan level tin beryllium adapted and expanded for different uses," said co-investigator Dr. Gabriela Romero Uribe, an subordinate professor astatine UT San Antonio's Klesse College of Engineering and Integrated Design.
The Connect programme is sponsored by nan Office of Research and Innovation astatine The University of Texas astatine San Antonio and nan Office of nan Executive Vice President and Chief Operating Officer astatine Southwest Research Institute. Smart biosensor investigation is 1 of 3 Connect programme grants awarded successful 2025.
"The advancement of subject and exertion cannot beryllium done without interdisciplinary collaboration. The Connect programme offers a awesome opportunity to initiate investigation that whitethorn perchance make caller and innovative technologies," said Uribe.
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