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8 hours ago
A squad of scientists astatine nan University of Seville has identified an basal process that protects DNA integrity successful reproductive cells, providing caller clues astir really organisms debar familial defects during ovum formation.
A precocious published study, nan consequence of Nuria Fernández-Fernández's doctoral work, describes really phosphorylation, a chemic modification of nan BRC-1/BRD-1 macromolecule analyzable successful nan Caenorhabditis elegans worm, acts arsenic a "switch" against DNA damage. This activation allows nan genome to repair itself decently during meiosis, nan process that gives emergence to reproductive cells.
When this system fails, nan DNA suffers superior breaks, starring to accumulated damage, chromosome fragmentation and nonaccomplishment of embryo viability. The researchers besides identified 2 enzymes, Bloom and Mus81, that lend to these problems by incorrectly resolving nan bonds betwixt damaged DNA molecules.
Our findings uncover a captious measurement successful nan cellular consequence to familial harm successful nan germline. Understanding these processes is basal to knowing really aneuploidy and developmental defects are prevented."
Dr. Tatiana García-Muse, main interrogator astatine nan Andalusian Centre for Molecular Biology and Regenerative Medicine (Cabimer)
The study highlights nan value of DNA repair systems successful fertility and patient improvement and could pave nan measurement for caller investigation into reproductive disorders successful humans.
Source:
Journal reference:
Fernández-Fernández, N., et al. (2025). Damage-induced phosphorylation of BRC-1/BRD-1 successful meiosis preserves germline integrity. Nucleic Acids Research. DOI: 10.1093/nar/gkaf945. https://academic.oup.com/nar/article/53/18/gkaf945/8262768
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