Retrospective Analyses Indicate Ozempic’s Protective Effects Against Stroke Fatality

Three studies presented coming astatine nan Society of NeuroInterventional Surgery's (SNIS) 22nd Annual Meeting discussed whether utilizing GLP-1 inhibitors could lessen nan impacts of changeable and related encephalon injuries aliases trim nan consequence of changeable altogether. These medications, which little humor sweetener and often origin weight loss, are commonly prescribed for type 2 glucosuria and obesity and see narcotics for illustration semaglutide (Ozempic).

In nan first study, "The Impact of Semaglutide (Ozempic) connected Mortality and Survival successful Patients pinch Acute Ischemic Stroke: A Nationwide and Institutional Retrospective Analysis," researchers astatine nan University of Wisconsin–Madison utilized diligent information from some nan university's aesculapian halfway and a world wellness collaborative to spot whether patients connected Ozempic who knowledgeable strokes had amended outcomes than patients not taking Ozempic.

The world dataset included 2,021,704 patients who had knowledgeable stroke, 43,338 of whom were besides connected Ozempic, and nan University of Wisconsin dataset included 13,510 group who had knowledgeable stroke, 190 of whom utilized Ozempic. Death from changeable was little for Ozempic users crossed some cohorts. In nan world dataset, 5.26% of Ozempic users initially died from their strokes compared to 21.61% of non-users, and Ozempic users besides had a 77.5% chance of surviving their strokes agelong word compared to 30.95% of non-Ozempic users. The assemblage cohort showed akin results, pinch 5.26% of Ozempic users dying from changeable versus 26.57% of patients not utilizing Ozempic.

In nan 2nd study, besides from nan University of Wisconsin–Madison, "Association betwixt Ozempic Use and Stroke Risk: A Nationwide Emergency Department Analysis," researchers examined a ample nationwide sample of emergency section records for group who knowledgeable changeable and group who were apt utilizing Ozempic. They recovered associations betwixt imaginable Ozempic users and importantly reduced likelihood of stroke. The investigation squad suggests taking this investigation further to measure information straight from pharmacies to beryllium moreover much precise astir nan narration betwixt Ozempic and changeable prevention.

The 3rd study, "Impact Of GLP-1 Agonists connected Stroke, SAH, and ICH: A Propensity-matched Multi-institutional Cohort Study," was presented by researchers from nan University of Texas Medical Branch successful Galveston. They investigated whether GLP-1 inhibitors could amended diligent outcomes aft encephalon hemorrhages (both spontaneous bleeds and those owed to encephalon aneurysm rupture) and stroke. The squad reviewed diligent records from 6 months and 12 months aft each encephalon hemorrhage and 1 twelvemonth and 2 years aft each stroke, uncovering that GLP-1 inhibitor usage was connected to a reduced consequence of cognitive broadside effects, seizures, early encephalon hemorrhage and decease aft encephalon hemorrhage and stroke.

According to Ahmed Elbayomy, MD, a investigation chap and information intelligence successful nan Department of Neurological Surgery astatine nan University of Wisconsin–Madison and superior writer of 2 of these studies, these results are very promising.

More investigation is surely needed, but seeing nan imaginable protection offered by these medications is simply a fascinating finding."

Ahmed Elbayomy, MD, Department of Neurological Surgery, University of Wisconsin–Madison 

"This investigation could present a caller position to nan chat of preventing and mitigating nan devastating effects of changeable and related encephalon injuries," added Matias Costa, MD, from nan Neurosurgery Department astatine nan University of Texas Medical Branch and writer of nan 3rd study.