Psma Pet/ct Improves Outcomes For Men With Recurrent Prostate Cancer

Using information collected nationwide complete a play of 8 years, researchers confirmed that PSMA PET/CT is simply a valuable instrumentality for identifying patients who are apt to use from salvage radiotherapy. This investigation was published successful nan August rumor of The Journal of Nuclear Medicine.

Biochemical recurrence aft extremist prostatectomy occurs successful up to 40 percent of prostate crab patients and salvage radiotherapy is recommended arsenic nan main curative option. With salvage radiotherapy, physicians trust connected imaging to precisely find recurrences for targeted treatment. While this imaging was antecedently performed pinch bony scintigraphy, CT, aliases MRI, nan fantabulous diagnostic capacity of PSMA PET/CT makes it nan existent modality of choice.

It is wide accepted that PSMA PET/CT is much meticulous than different imaging methods for returning prostate cancer, and that it often changes diligent curen strategies, said Anna W. Mogensen, MSc, a PhD student astatine nan Department of Nuclear Medicine astatine Aalborg University Hospital successful Aalborg, Denmark. Nevertheless, it has remained unclear whether PSMA PET/CT guided changes successful curen strategy led to improved survival.

She continued, PSMA PET/CT was introduced successful Denmark successful 2015; nevertheless not each regions adopted nan imaging modality astatine once. Utilizing Denmark s nationwide wellness registry, my colleagues and I compiled a ample and broad dataset to comparison nan wide endurance betwixt patients who underwent PSMA PET/CT earlier salvage radiotherapy and those who did not.

The study utilized information obtained from regular objective believe of each patients treated pinch salvage radiotherapy successful Denmark from 2015 done 2023. In total, 844 patients were categorized according to whether they underwent pretreatment PSMA PET/CT (308 patients) aliases did not (536 patients). Researchers compared nan wide survival, arsenic good arsenic biochemical recurrence-free survival, for up to 5 years aft completion of salvage radiotherapy. 

The study revealed greater wide endurance for patients who underwent PSMA PET/CT earlier salvage radiotherapy than for patients who did not. The one-, two-, and five-year endurance rates for PSMA PET/CT patients were 100, 99.5, and 98.1 percent, respectively, versus 99, 97.8, and 93.8 percent, respectively, for non-PSMA PET/CT patients.

The three-year biochemical recurrence-free endurance complaint was accordant pinch wide survival: 74.9 percent for PSMA PET/CT patients and 69.4 percent for non-PSMA PET/CT patients.

Our findings show that PSMA PET/CT scans tin thief clinicians prime nan patients astir apt to acquisition occurrence pinch salvage radiotherapy. This intends less patients whitethorn person unnecessary treatment, while much will beryllium provided pinch nan due care, Mogensen said. These findings support broader usage of atomic medicine techniques to guideline therapy and propose that integrating imaging early successful curen decisions could go a caller modular successful crab care.

Source:

Journal reference:

Mogensen, A. W., et al. (2025) The Use of PSMA PET/CT Improves Overall Survival successful Men pinch Biochemically Recurrent Prostate Cancer Treated pinch Salvage Radiotherapy: Real-World Data from an Entire Country. Journal of Nuclear Medicine. doi.org/10.2967/jnumed.125.269996