Promega Unveils Cellular Target Engagement Technology Aimed At Expanding The Druggable Proteome At Slas 2026

Promega Corporation is launching a caller live-cell target engagement level that could adjacent a long-standing spread betwixt biochemical and cellular assays for understudied aliases difficult-to-interrogate proteins. The TarSeer™ BRETSA™ Target Engagement System is simply a caller bioluminescence resonance power transfer-based displacement assay for detecting ligand-protein interactions successful intact cells utilizing macromolecule denaturation. It gives supplier find researchers early, target-specific cellular insights by validating anemic aliases early chemic matter and expanding nan targets accessible successful live-cell supplier find workflows. The exertion will beryllium debuted astatine nan Society for Laboratory Automation and Screening (SLAS) International Conference and Exhibition successful Boston, 7 to 11 February 2026.

You tin now perchance study intracellular target engagement for immoderate macromolecule successful unrecorded cells, This level will springiness supplier find researchers caller starting points to spell aft a immense fraction of antecedently intractable therapeutic targets wrong nan quality proteome."

Matt Robers, Associate Director of R&D, Promega

Drug find teams tin place biochemical hits that neglect to construe successful cellular settings. A deficiency of target-specific cellular assays, particularly for difficult aliases intractable targets, stalls deed validation and lead optimization. BRETSA is designed to thief flooded this situation by measuring compound binding to target proteins straight successful cells via changes successful target macromolecule thermal stability, moreover erstwhile targets deficiency known chemic probes aliases binding pockets are poorly defined. This early cellular characterization of target-ligand potency reduces uncertainty and increases early-stage assurance successful compound prioritization.

Advantages of nan TarSeer™ BRETSA™ Target Engagement System include:

• Enhanced sensitivity: Researchers tin measurement potency and rank-order compound binding successful unrecorded cells, including anemic interactions that are difficult to quantitate aliases are moreover missed successful early discovery.
• Broad applicability: The level has been applied to much than 20 target classes and aggregate cellular compartments, supporting studies of proteins that deficiency established cellular assays.
• Flexible, scalable workflow: An addition-only workflow compatible pinch 96- and 384-well formats allows teams to standard from focused follow-up to higher-throughput experiments.

Matt Robers will present nan level and coming information crossed aggregate target classes during a podium position titled "BRETSA: An ultra-sensitive, broadly-applicable BRET method to measurement target engagement done macromolecule denaturation successful unrecorded cells" astatine SLAS 2026. The talk will return spot astatine 3:30 p.m. connected Tuesday, February 10, 2026. Promega unit will beryllium disposable passim nan convention successful Booth #1448 to talk nan technology.

The TarSeer™ BRETSA™ Target Engagement System builds connected nan agelong occurrence of nan Promega NanoBRET® Target Engagement System, which besides uses BRET to quantify cellular target engagement. The BRETSA level complements NanoBRET methods by addressing targets that deficiency suitable probes for NanoBRET analysis. By expanding this toolbox, Promega deepens its support for researchers processing mini molecule narcotics against a wide scope of disease-relevant proteins.

Video Credit: Promega Corporation