Missing The First Mammogram Raises Risk Of Advanced Breast Cancer

Women who miss their first mammogram tally a higher consequence of being diagnosed pinch precocious bosom crab and dying from nan disease. This is shown successful a caller study from Karolinska Institutet published successful nan technological diary BMJ.

Since nan early 1990s, women successful Sweden person been offered regular mammograms, which has contributed to a alteration successful bosom crab mortality. Despite this, a important proportionality take not to be their first examination. The researchers down nan caller study wanted to analyse nan semipermanent consequences of this. The study is based connected information from nan Swedish mammography screening programme and nationalist wellness registries, and covers almost 433,000 women successful Stockholm betwixt 1991 and 2020, pinch follow-up for up to 25 years. The results show that 32 percent of each women who were invited to their first screening declined. These women were besides little apt to participate successful early examinations, which often led to a later test and poorer prognosis.

Skipping nan first mammogram is simply a beardown parameter of who is astatine consequence of precocious discovery and higher mortality. Our results show that missing nan first mammogram is not conscionable a one-time choice, but often marks nan opening of a semipermanent shape of not attending check-ups."

Ziyan Ma, study's first author, doctoral student, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet

When women who skipped their first screening were later diagnosed pinch bosom cancer, nan illness was much often detected astatine a much precocious stage. The consequence of processing shape III crab was astir 1.5 times higher, and for shape IV, nan consequence was arsenic overmuch arsenic 3.6 times higher compared to those who participated successful nan first mammogram. Over a 25-year follow-up period, almost 1 percent of those who did not participate had died of bosom cancer, compared pinch 0.7 percent among nan participants – a quality that corresponds to a 40 percent higher consequence of dying from nan disease. However, nan full proportionality of women who developed bosom crab was almost nan aforesaid successful some groups, astir 7.7 percent. According to nan researchers, this shows that nan accrued mortality is chiefly owed to delayed discovery alternatively than much cases of nan disease.

"Family history is simply a well-known, unchangeable consequence facet for bosom cancer. Our study shows that missing nan very first screening introspection carries a akin mortality consequence – but dissimilar family history, this is simply a behaviour that we tin change. Since complete 30 percent of women skip their first screening, accrued information could prevention galore lives. Since this group tin beryllium identified early, decades earlier deaths occur, healthcare providers person a chance to intervene pinch reminders aliases support to promote participation, says nan study's past author, Kamila Czene, professor astatine nan Department of Medical Epidemiology and Biostatistics, Karolinska Institutet

Important partners see Zhejiang University successful China and objective collaborations pinch Södersjukhuset and S:t Görans Sjukhus. The study was funded by nan Swedish Research Council and nan Swedish Cancer Society.