A Mediterranean-style diet, rich | successful fiber, rootlike proteins and patient fats, benefits maternal wellness during gestation and breastfeeding. In summation to improving intestinal usability and mucosal immunity, it besides prevents fat accumulation and optimizes nan creation of nan microbiota successful nan digestive system. In babies, this maternal dietary shape helps to trim nan incidence and severity of infections.
These conclusions travel from 2 studies published successful nan diary eBioMedicine, carried retired pinch nan support of La Marató de TV3 (2017). The investigation was jointly led by Francisco José Pérez-Cano, professor astatine nan Faculty of Pharmacy and Food Sciences of nan University of Barcelona and head of nan Nutrition and Food Safety Research Institute (INSA-UB), based astatine nan UB's Torribera Food Campus, and nan master M. Carmen Collado, from nan Institute of Agrochemistry and Food Technology (IATA-CSIC).
Led by interrogator Karla Rio Aige (INSA-UB) arsenic first author, nan studies, coordinated globally by nan UB, utilized information from nan MAMI (Maternal Microbiome) cohort to place applicable observations. Researchers besides developed a preclinical exemplary pinch animal models utilizing nan diets detected successful nan cohort pinch nan purpose of knowing nan mechanisms of action involved.
Nutrition and mother-child health: galore unfastened questions
A balanced fare and a patient manner and habits are important for bully wellness successful pregnancy. Therefore, establishing optimal nutritional habits during pregnancy, lactation and early life is important for nan wellness and well-being of mother and baby. However, nan associated mechanisms linking maternal fare to maternal and babe wellness outcomes are still poorly understood.
María José Rodríguez Lagunas, a personnel of nan project's investigation squad and of nan UB's Department of Biochemistry and Physiology, notes that knowing really maternal fare influences mother and babe physiology "is crucial, arsenic its effects widen to short- and semipermanent outcomes for some mother and child." However, she adds that "there is simply a notable deficiency of investigation connected nan underlying mechanisms, peculiarly those that could amended nan physiological betterment of nan mother aft childbirth".
The first study, astatine nan preclinical level, compared nan effects of 2 different diets during gestation and lactation connected microbiota composition, immunity and lipid metabolism: nan Mediterranean-like D1 diet, rich | successful fibre and rootlike protein, and a Western D2 diet, richer successful animal macromolecule and fats. During nan nutritional intervention, various biologic samples were analysed to spot nan effects of each fare connected nan epithelial barrier, lipid metabolism, microbiota composition, metabolites and immunity.
The results uncover that a fare akin to nan Mediterranean fare and enriched pinch food oil, soya macromolecule and inulin has beneficial effects connected lipid metabolism, nan creation of nan microbiota and nan immune consequence during gestation and breastfeeding, and improves maternal health."
Professor Francisco J. Pérez-Cano
"Furthermore, if this fare is maintained during breastfeeding, it seems to much efficaciously reverse nan physiological changes that hap during pregnancy, supporting immune usability and limiting fat accumulation," adds nan expert.
Improving kid wellness done maternal diet
The 2nd study shows that a maternal fare rich | successful works protein, fibre and polyunsaturated fatty acids reduces nan severity and wave of infections successful infants done nan modulating effect of gut microbiota connected nan immune system.
The study, conducted connected infants and animal models, analyses nan effect of maternal fare connected nan wellness of offspring and reinforces nan value of maternal nutrition during gestation and lactation to fortify babe health. The synergy of nan INSA-UB and IATA-CSIC teams — institutions recognized pinch nan María de Maeztu and Severo Ochoa seals of excellence, respectively — was cardinal to obtaining nan results.
In this context, nan power of nan maternal fare emerges arsenic a cardinal facet successful nan creation of nan protect elements of beverage during lactation. As basal elements, immunoglobulin A (IgA) successful quality beverage and nan diverseness of nan microbiota show their protective domiciled against infections successful infants.
These studies supply caller insights that whitethorn lead to much precise dietary guidelines for pregnant and breastfeeding women. On nan 1 hand, they would thief to fortify nan wellness of mothers and support their physiological recovery, and connected nan different hand, they would protect babe improvement successful nan early stages of life by reducing nan consequence of infections, frankincense supporting nan wellbeing of babies.
"The study whitethorn besides thief to amended understand nan narration betwixt maternal diet, bioactive components of bosom milk, babe microbiota and babe immunity. In nan future, further investigation will beryllium basal to get much coagulated conclusions and amended understand nan mechanisms involved," reason experts M. Carmen Collado and Francisco José Pérez-Cano.
Source:
Journal reference:
Rio-Aige, K., et al. (2025). A fare rich | successful fibre and rootlike macromolecule during gestation and lactation shapes maternal immunity, intestinal microbiota and lipid metabolism. eBioMedicine. doi.org/10.1016/j.ebiom.2025.105784
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