Long-term Study Shows Peanut Patch Treatment Builds Tolerance In Toddlers

New investigation presented astatine nan 2025 Annual Scientific Meeting of nan American College of Allergy, Asthma and Immunology (ACAAI) offers encouraging news for parents of young children pinch peanut allergies. A semipermanent study recovered that a peanut spot curen – epicutaneous immunotherapy – continued to thief toddlers safely build tolerance to peanuts complete 3 years.

The treatment, known arsenic nan Viaskin Peanut Patch, delivers mini amounts of peanut macromolecule done nan skin. The extremity is to train nan immune strategy to tolerate peanut vulnerability and trim nan consequence of terrible allergic reactions from accidental ingestion.

This caller study looked astatine toddlers who primitively received placebo successful an earlier one-year study and past utilized nan peanut spot for up to 3 years. After 3 years of treatment, much than 70% of these children could tolerate nan balanced of astatine slightest 3 to 4 peanut kernels – a important betterment from their first twelvemonth of treatment. Nearly half could tolerate moreover higher amounts.

Importantly, nan curen continued to show a beardown information record. No cases of treatment-related anaphylaxis (a terrible allergic reaction) were reported successful nan 3rd year. Skin irritation astatine nan spot tract – nan astir communal broadside effect – became little predominant complete time. Researchers besides recovered that children's reactions during nutrient challenges became milder, pinch less terrible symptoms aft 3 years than aft 1 year.

These results show that ongoing curen pinch nan peanut spot continues to amended tolerance and remains safe complete time. For parents of toddlers pinch peanut allergies, this benignant of attack whitethorn 1 time connection bid of mind by reducing nan consequence of having an allergic reaction, including terrible reactions, from accidental exposure."

Matthew Greenhawt, MD, MBA, allergist, lead writer and ACAAI member

Peanut allergy affects astir 2% of children successful nan U.S. and is simply a starring origin of terrible allergic reactions. The study results adhd to increasing grounds that early involution successful young children could thief alteration nan people of peanut allergy. Researchers accent that parents should not effort immoderate shape of peanut desensitization astatine location and should talk emerging curen options pinch a board-certified allergist.

The investigation was funded by DBV Technologies.

Abstract Title: Long-Term Efficacy and Safety of Epicutaneous Immunotherapy successful Peanut-Allergic Toddlers: Epopex End of Study Results

Presenter: Matthew Greenhawt, MD, MBA