Investigating Cannabidiol's Role In Combating Alzheimer's-related Neuroinflammation

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Neuroinflammation damages neurons and tin lend to diseases for illustration Alzheimer's. Cannabidiol (CBD) has anti-inflammatory properties, which suggests that it could combat neuroinflammation successful Alzheimer's. In a caller eNeuro paper, Babak Baban and colleagues, from Augusta University, explored whether CBD tin beryllium leveraged arsenic an antiinflammatory curen successful an established Alzheimer's illness rodent model. 

The researchers assessed 2 chopped mechanisms for shaping immune responses and regulating neuroinflammation successful nan cardinal nervous system pursuing CBD curen via inhalation. With respective molecular and familial measures, they discovered that CBD reduced look of cardinal regulators for neuroinflammation successful Alzheimer's mice, which was associated pinch little proinflammatory molecules. Baban et al. besides identified chopped regulators of nan immune consequence and neuroinflammation pinch which CBD interacted. 

Alzheimer's activity has agelong centered connected plaques and tangles. But our study shows that chronic autoinflammation is besides a halfway driver of nan disease. What's breathtaking is that CBD not only calms this immune overactivation but, successful earlier work, we've shown it tin besides thief clear plaques and tangles done a different mechanism. Together, this points to a multitarget attack pinch existent therapeutic potential." 

Babak Baban, Augusta University

Source:

Journal reference:

Naeini, S. E., et al. (2025) Rethinking Alzheimer's: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation Control. eNeuro. doi.org/10.1523/ENEURO.0114-25.2025

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