Intermittent Energy Restriction Shows Strong Benefits For People With Obesity And Type 2 Diabetes

Intermittent power restriction, time-restricted eating and continuous power regularisation tin each amended humor sweetener levels and assemblage weight successful group pinch obesity and type 2 diabetes, according to a study being presented Sunday astatine ENDO 2025, nan Endocrine Society's yearly gathering successful San Francisco, Calif.

"This study is nan first to comparison nan effects of 3 different dietary interventions intermittent power regularisation (IER), time-restricted eating (TRE) and continuous power regularisation (CER) successful managing type 2 glucosuria pinch obesity," said Haohao Zhang, Ph.D., main expert astatine The First Affiliated Hospital of Zhengzhou University successful Zhengzhou, China.

Although researchers identified improved HbA1c levels, and adverse events were akin crossed nan 3 groups, nan IER group showed greater advantages successful reducing fasting humor glucose, improving insulin sensitivity, lowering triglycerides, and strengthening adherence to nan dietary interventions.

"The investigation fills a spread successful straight comparing 5:2 intermittent power regularisation pinch a 10-hour time-restricted eating successful patients pinch obesity and type 2 diabetes. The findings supply technological grounds for clinicians to take due dietary strategies erstwhile treating specified patients," Zhang said.

Zhang and colleagues performed a single-center, randomized, parallel-controlled proceedings astatine nan First Affiliated Hospital of Zhengzhou University from November 19, 2021 to November 7, 2024.

Ninety patients were randomly assigned successful a 1:1:1 ratio to nan IER, TRE aliases CER group, pinch accordant play caloric intake crossed each groups. A squad of nutritionists supervised nan 16-week intervention.

Of those enrolled, 63 completed nan study. There were 18 females and 45 males, pinch an mean property of 36.8 years, a mean glucosuria long of 1.5 years, a baseline BMI of 31.7 kg/m², and an HbA1c of 7.42%.

At nan extremity of nan study, location were nary important differences successful HbA1c simplification and weight nonaccomplishment betwixt nan IER, TRE and CER groups. However, nan absolute alteration successful HbA1c and assemblage weight was top successful nan IER group.

Compared to TRE and CER, IER importantly reduced fasting humor glucose and triglycerides and accrued nan Matsuda index, a measurement of whole-body insulin sensitivity. Uric acerb and liver enzyme levels exhibited nary statistically important changes from baseline successful immoderate study group.

Two patients successful nan IER group and nan TRE group, and 3 patients successful nan CER group, knowledgeable mild hypoglycemia.

The IER group had nan highest adherence complaint (85%), followed by nan CER group astatine 84% and nan TRE group astatine 78%. Both nan IER and CER groups showed statistically important differences compared pinch nan TRE group.

Zhang said these findings item nan feasibility and effectiveness of dietary interventions for group who person obesity and type 2 diabetes.