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2 months ago
A multi-center, randomized shape III proceedings has recovered that a three-week hypofractionated radiotherapy (HypoRT) schedule pinch concurrent chemotherapy provides akin endurance outcomes and reduced toxicity compared to nan modular six-week accepted fractionated radiotherapy (ConvRT) schedule for patients pinch limited-stage mini compartment lung crab (LS-SCLC).
The results were presented coming astatine nan International Association for nan Study of Lung Cancer (IASLC) 2025 World Conference connected Lung Cancer (WCLC).
In hypofractionated radiotherapy for lung crab treatment, clinicians present less radiation treatments (fractions) astatine higher doses per convention compared to modular radiotherapy schedules.
The study, conducted crossed 16 hospitals successful China, randomized 530 patients to person either HypoRT (45 Gy successful 15 regular fractions complete 3 weeks) aliases ConvRT (60 Gy successful 30 regular fractions complete 6 weeks), some fixed pinch concurrent cisplatin/carboplatin-etoposide chemotherapy. At a median follow-up of 43.4 months, median wide endurance (OS) was 40.2 months successful nan HypoRT limb and 47.9 months successful nan ConvRT limb (HR=1.04; 95% CI, 0.81–1.33). Progression-free endurance was besides akin betwixt nan groups.
Patients receiving HypoRT knowledgeable importantly less terrible treatment-related adverse events including little rates of hematologic toxicity, lymphopenia, and radiation pneumonitis. Acute people ≥3 adverse events occurred successful 48.7% of HypoRT patients compared to 67.7% successful nan ConvRT group.
Our findings propose that hypofractionated radiotherapy tin supply a shorter, much convenient curen people pinch less broadside effects while maintaining comparable endurance outcomes to accepted radiotherapy. This attack could beryllium an important action for patients, particularly successful settings wherever reducing curen clip and toxicity is simply a priority."
Nan Bi, MD, The National Cancer Center of China/Cancer Hospital, Chinese Academy of Medical Sciences, Beijing
The investigators statement that further investigation is warranted to research HypoRT successful operation pinch immunotherapy fixed its imaginable immune-sparing benefits.
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