Guideline-based Prostate Cancer Treatment Helps Most Men Outlive The Disease

3 days ago

Most men who are treated for prostate crab according to modern guidelines person bully endurance rates and nan mostly of these men will dice of causes different than prostate cancer. This is revealed successful a caller study from Uppsala University published successful nan Journal of nan National Comprehensive Cancer Network.

"We were amazed by really overmuch life expectancy affected nan prognosis. This shows nan value of a thorough appraisal of nan wide wellness of a man pinch recently diagnosed prostate cancer. The patient's life expectancy has a important effect connected nan prime of due curen strategy," says Marcus Westerberg, interrogator astatine nan Department of Surgical Sciences astatine Uppsala University, who led nan study.

In prostate cancer, nan illness progression often takes decades and nan consequence of dying from prostate crab truthful depends connected some nan characteristics of nan crab and life expectancy based connected nan man's property and different diseases astatine nan clip of diagnosis. Recommendations successful guidelines and attraction programmes are truthful besides based connected some crab characteristics and life expectancy. This intends that nan recommended first curen tin scope from progressive monitoring for low-risk crab to combinations of section and systemic curen for high-risk cancer.

High mean property astatine illness onset

As nan mean property astatine test of prostate crab is often precocious and nan crab often progresses very slowly, it is peculiarly important to cognize nan semipermanent consequence of decease from prostate crab successful bid to take nan champion curen for patients. Previously, not overmuch has been known astir this.

We wanted to capable that knowledge gap, truthful we looked astatine outcomes up to 30 years aft nan men were diagnosed. In each cases, we had accusation astir nan characteristics of nan cancer, curen and nan patient's life expectancy based connected property and comorbidity."

Marcus Westerberg, Researcher, Department of Surgical Sciences, Uppsala University

The researchers utilized information from nan Prostate Cancer Database Sweden (PCBase), which contains accusation from nan National Prostate Cancer Register (NPCR) and different wellness information registers. They focused connected men who had received nan recommended curen for prostate crab that had not dispersed successful nan body. Using statistical modelling, nan researchers estimated nan life consequence of dying from prostate crab and different causes.

11 per cent consequence of dying of cancer

For men pinch low-risk crab and short life expectancy (less than 10 years), nan consequence of dying from prostate crab was 11 per cent and nan consequence of dying from different causes was 89 per cent wrong 30 years of diagnosis.

For men pinch high-risk crab (e.g. shape T3, PSA 30 ng/ml and Gleason people 8) and agelong life expectancy (over 15 years), nan consequence of dying from prostate crab was 34 per cent and nan consequence of dying from different causes was 55 per cent wrong 30 years of diagnosis.

"We dream that our results will beryllium utilized to supply a realistic image of nan prognosis for men pinch prostate cancer. Our study shows that astir men who person nan recommended curen person a bully prognosis," Westerberg concludes.

Life expectancy was based connected property and comorbidity. Examples of low-risk cancers are shape T1, PSA 5 ng/ml and Gleason people 6. Examples of high-risk cancers are shape T3, PSA 30 ng/ml and Gleason people 8.

Source:

Journal reference:

Scilipoti, P., et al. (2025). Long-Term Outcomes After Guideline-Recommended Treatment of Men With Prostate Cancer. Journal of nan National Comprehensive Cancer Network. doi.org/10.6004/jnccn.2025.7022.

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