Glucose-fructose Mix Found In Sugary Drinks Fuels Colorectal Cancer Metastasis

A caller study from researchers astatine The University of Texas MD Anderson Cancer Center shows that nan glucose-fructose operation recovered successful sugary drinks straight fuels metastasis successful preclinical models of precocious colorectal cancer. The study was published coming successful Nature Metabolism.

What are nan cardinal findings of this study?

A investigation squad led by Jihye Yun, Ph.D., adjunct professor of Genetics, studied really sugary drinks whitethorn impact late-stage colorectal cancer. Using laboratory crab models, they compared nan effects of nan glucose-fructose operation recovered successful astir sugary drinks pinch those of glucose aliases fructose alone. Only nan sweetener operation made crab cells much mobile, starring to faster dispersed to nan liver - nan astir communal tract of colorectal crab metastasis.

The sweetener operation activated an enzyme called sorbitol dehydrogenase (SORD), which boosts glucose metabolism and triggers nan cholesterin pathway, yet driving metastasis. This is nan aforesaid pathway targeted by statins, communal bosom narcotics that inhibit cholesterin production. Blocking SORD slowed metastasis, moreover pinch nan sweetener operation present. These findings propose that targeting SORD could besides connection an opportunity to artifact metastasis.

Our findings item that regular fare matters not only for crab consequence but besides for really nan illness progresses erstwhile it has developed. While these findings request further investigation, they propose that reducing sugary drinks, targeting SORD aliases repurposing statins whitethorn use patients pinch colorectal cancer."

Jihye Yun, Ph.D., adjunct professor of genetics, The University of Texas MD Anderson Cancer Center 

Why did nan researchers study sugary drinks successful colorectal cancer?

The Yun Laboratory is willing successful studying really fare affects nan intestine and crab development, and they person made important discoveries connected nan impacts of sugary drinks connected colorectal cancer.

Sugar has agelong been indirectly linked to an summation successful crab consequence done obesity. However, a erstwhile study by Yun's laboratory challenged that view, showing that moreover mean intake of sugary drinks straight fueled tumor maturation successful early-stage colorectal cancer, independent of obesity. The existent study was done to find really sugary drinks whitethorn effect later-stage disease.

What does this study mean for patients and nan public?

While this study needs further objective investigation, nan results propose that reducing sugary drinks and targeting nan SORD enzyme whitethorn connection opportunities to trim colorectal crab metastasis. Additional studies are warranted to corroborate these results extracurricular of preclinical models.

Further, Yun explained it whitethorn beryllium worthwhile to see revisions to existent dietary recommendations to trim sugary portion depletion successful this diligent population. To meet nutritional needs, galore patients pinch crab are encouraged to person nutritional supplement drinks and concentrated juices that incorporate precocious glucose and fructose content.

This study was supported by nan National Cancer Institute (NCI), nan Pew-Stewart Scholars for Cancer Research program, nan Cancer Prevention and Research Institute of Texas (CPRIT), nan V Scholar Award, and nan Andrew Sabin Family Fellows Award.