Glp-1 Drugs Linked To Improved Survival In Colon Cancer Patients

A caller University of California San Diego study offers compelling grounds that glucagon-like peptide-1 (GLP-1) receptor agonists - nan people of narcotics down Ozempic, Wegovy and Mounjaro, for illustration - whitethorn do much than modulate humor sweetener and weight. In an study of much than 6,800 colon crab patients crossed each University of California Health sites, researchers recovered that those taking GLP-1 medications were little than half arsenic apt to dice wrong 5 years compared to those who weren't connected nan narcotics (15.5% versus 37.1%).

The study, led by Raphael Cuomo, Ph.D., subordinate professor successful nan Department of Anesthesiology astatine UC San Diego School of Medicine and personnel of UC San Diego Moores Cancer Center, utilized real-world objective information from nan University of California Health Data Warehouse to measure outcomes crossed nan state's world aesculapian centers. After adjusting for age, assemblage wide scale (BMI), illness severity and different wellness factors, GLP-1 users still showed importantly little likelihood of death, suggesting a beardown and independent protective effect.

The endurance use appeared astir pronounced successful patients pinch very precocious BMI (over 35), hinting that GLP-1 narcotics whitethorn thief counteract nan inflammatory and metabolic conditions that worsen colon crab prognosis. Researchers judge respective biologic mechanisms could explicate nan link. Beyond regulating humor sugar, GLP-1 receptor agonists trim systemic inflammation, amended insulin sensitivity and beforehand weight nonaccomplishment - each factors that tin dampen tumor-promoting pathways. Laboratory studies besides propose that GLP-1 narcotics whitethorn straight forestall crab compartment growth, trigger crab compartment decease and reshape nan tumor microenvironment. However, nan study authors stress that much investigation is needed to corroborate these mechanisms and find whether nan endurance use observed successful this real-world study represents a nonstop anti-cancer effect aliases an indirect consequence of improved metabolic health.

Cuomo notes that while these results are observational, they underscore an urgent request for objective tests to trial whether GLP-1 narcotics tin amended crab endurance rates, particularly for patients pinch obesity-related cancers.

The study appeared successful Cancer Investigation connected Nov. 11, 2025.