Dkms Advances Blood Cancer Research With Groundbreaking Asap Study

The action of patients for allo-HSCT and nan champion attack to bridging patients to transplantation is continuously discussed by experts. The first results of nan ASAP study (ASAP opinionated for "as soon arsenic possible"), published successful 2024, person already attracted sizeable attention. ASAP questions existing curen standards for AML and was nan first randomized controlled proceedings to comparison remission induction pinch salvage chemotherapy prior to allo-HSCT – which represents nan existent modular of attraction (SOC) – against an replacement attack of contiguous transplantation aft intensified conditioning mixed pinch non-intensive illness power strategies specified arsenic little fierce chemotherapy aliases elemental monitoring of leukemic proliferation. These 2 groups are referred to arsenic nan SOC limb and nan replacement curen arm, respectively.

ASAP: Transplantation arsenic soon arsenic possible

The now published semipermanent study supports nan first results of nan ASAP trial. The findings suggest, that a transplantation arsenic soon arsenic imaginable yields comparable curen outcomes arsenic remission induction – pinch shorter infirmary stays and reduced vulnerability to chemotherapy.

The results mobility nan world modular of leukemia treatment. We nary longer request to springiness each patients a very fierce chemotherapy to trim nan tumor load up of transplantation erstwhile regimens pinch bully anti-leukemic activity are utilized for conditioning connected nan days anterior to stem compartment transplantation."

Prof. Dr. Johannes Schetelig, coauthor of nan study

The results were based connected a median follow-up of 61 months successful nan diligent cohort: The induction of remission successful nan SOC limb (5-year OS: 47.5%) compared to contiguous transplantation successful nan replacement curen limb (5-year OS: 46.1%) showed nary wide endurance (OS) advantage successful AML patients, which were poorly responsive to first curen aliases pinch untreated relapse. Since non-inferiority could not beryllium demonstrated formally, contiguous transplantation will not switch nan communal SOC but tin beryllium considered much often today. One statement successful favour of proceeding straight to transplantation without remission induction is that patients who received intensive salvage chemotherapy successful nan SOC limb spent 1 period longer successful infirmary and knowledgeable much adverse events.

Age and AML genetics are nan astir important consequence factors influencing survival

The semipermanent follow-up of ASAP additionally analyzed curen occurrence according to consequence classification and familial subgroups. Both property and AML genetics were identified arsenic nan astir important baseline consequence factors influencing survival. AML genetics were classified according to nan ELN 2022 criteria.

The wide endurance probabilities astatine 5 years (5-year OS) from randomization successful nan different consequence groups independent from curen limb were:

• 66% pinch favorable consequence AML,
• 53% pinch intermediate consequence AML, and
• 34% for adverse consequence AML.

When some nan ELN consequence and nan curen were taken into account, nan 3-year wide endurance was 77% for patients pinch favorable/intermediate AML pinch watchful waiting successful nan replacement curen limb (N = 49) versus 66% for patients transplanted pinch complete remission successful nan SOC limb successful nan aforesaid consequence group (N = 49) [1].

An important measurement towards precision medicine successful transplantation

"In summary, it tin beryllium concluded that endurance aft allo-HSCT successful AML patients is little influenced by remission induction aliases bridging strategies and much influenced by intrinsic illness biology," concludes Prof. Schetelig.

Interestingly, reducing nan pre-transplant leukemia load did not construe into improved endurance erstwhile intensive cytotoxic regimens were used, challenging a communal presumption successful curen planning.

The uncertain benefits of inducing remission anterior to allo-HSCT are successful opposition to nan basal effect of AML genetics. Favorable consequence AML was associated pinch higher endurance rates compared to adverse consequence AML. These findings are accordant pinch erstwhile reports connected nan prognostic effect of nan ELN 2022 classification successful patients undergoing allogeneic stem compartment transplantation. "But nan information of nan ASAP proceedings besides show that tolerable caller bridging therapies and posttransplant attraction for much personalized strategies are urgently warranted, particularly for adverse consequence AML, to amended outcomes aft allo-HSCT," summarizes Prof. Dr. Johannes Schetelig. "These findings unfastened nan doorway for early investigation to place circumstantial AML subgroups – a cardinal measurement towards precision medicine successful transplantation."

DKMS fosters technological progress

The ASAP study, initiated and realized by DKMS, reflects nan attraction connected various areas of invention to conflict humor crab from each angle. "It is our declared extremity to amended nan endurance and treatment chances for patients pinch humor crab by investing successful investigation to heighten existent treatments and research innovative approaches," highlights Dr. Elke Neujahr, Global CEO DKMS.

As an world non-profit organization, DKMS places typical value connected technological questions that are not driven by commercialized interests. This includes investigation that helps to alteration entree to holistic treatments worldwide, aliases that critically examines nan usage of existent modular treatments. DKMS partners pinch aesculapian experts crossed continents to foster technological progress, costs investigation projects connected an world level, conducts objective trials, and honors outstanding technological activity pinch nan DKMS Mechtild Harf Science Award. With nan DKMS John Hansen Research Grant nan statement supports actively young scientists pinch innovative approaches successful nan section of humor crab (current exertion deadline: November 20, 2025). Find retired much astir each technological accusation astatine DKMS Professionals' Platform.