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At nan Neuroscience 2025 conference, Bruker Corporation coming announced nan merchandise of the xView Module for Ultima 2Pplus multiphoton microscopes to importantly widen imaging standard and research elasticity for precocious neuroscience research. This patent-pending upgrade enhances nan field-of-view (FOV) of Ultima systems by much than 2.5 times to alteration high-resolution imaging of neural activity crossed larger encephalon areas, without compromising velocity or sensitivity.
The xView Module for Ultima 2Pplus Multiphoton Microscopes. Image Credit: Bruker
Engineered to meet nan increasing demands of systems neuroscience research, the xView Module empowers researchers to visualize much expansive neural circuits successful tandem pinch optogenetic activation, utilizing Bruker’s NeuraLight 3D Ultra Module for holographic photostimulation. This unprecedented commercialized pairing of a immense imaging FOV pinch complementary large-volume optogenetics makes it imaginable to study input-output relationships and manipulate wide neuronal networks for insights toward brain-wide connectivity and function. The xView Module is peculiarly suited for broader imaging studies of epileptic activity crossed nan encephalon and circuit mapping for knowing mechanisms of Alzheimer's and Parkinson’s diseases.
“Over nan past months I person been using xView to study nan spatial and temporal properties of circuits crossed cortical encephalon regions, wherever nan summation successful FOV has been captious to execute meaningful data,” said Associate Professor Caroline Runyan of nan University of Pittsburgh, Department of Neuroscience. “I americium excited to beryllium capable to harvester this caller capacity pinch 3D optogenetics connected our Ultima 2Pplus microscopes.”
The xView Module unlocks a caller standard of imaging for neuroscience,
By expanding nan FOV while maintaining optical precision, we are continuing to build upon nan Ultima platform’s occurrence and investigation capabilities and push nan limits of imaging instrumentation. We are looking guardant to seeing nan benefits and discoveries this helps bring to nan technological community.”
Xiaomei Li, Ph.D., Vice President and General Manager, Bruker’s Fluorescence Microscopy Business
About the xView Module
xView Module extends nan Ultima 2Pplus multiphoton microscope’s FOV utilizing Bruker’s patented ETL correction, enabling high-resolution imaging crossed millimeter-scale encephalon regions. By compensating for communal image aberrations successful ample fields of view, xView maintains near-standard constituent dispersed usability capacity while expanding FOV beyond accepted limits. In addition, nan integration of xView with Ultima’s xCore FPGA electronics provides elasticity to grounds crossed larger areas pinch greater-than-video-rate speeds aliases pinch ultra-high fidelity, up to 8K resolution. The Ultima 2Pplus level pinch SLM and xView Module provides nan market’s astir broad solution for mesoscale neural circuit studies without sacrificing velocity or resolution.
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