Automation In Cell-based Workflows

In this interview, manufacture master Dongmin Choi explains nan value of automated imaging and colony picking. He dives into really they amended consistency, reproducibility, and information value successful cell-based workflows, enabling much businesslike investigation and amended semipermanent experimental insights. 

Please tin you present yourself and your domiciled astatine Curiosis?

My sanction is Dongmin, and I americium a income head astatine Curiosis. I activity intimately pinch distribution partners and researchers astir nan world, supporting some nan preamble of our products and their exertion successful existent laboratory environments.

My domiciled involves ensuring that our partners person nan method and commercialized support they need, while besides helping researchers understand really our systems tin amended their workflows and information quality.

Before we get into nan circumstantial technologies, could you stock immoderate penetration into nan biggest challenges researchers look coming successful managing analyzable cell-based workflows?

Cell-based assays impact complex, multi-step processes, and 1 of nan biggest challenges is maintaining consistency crossed experiments. Researchers often woody pinch important manual labor, and quality correction tin easy impact reproducibility.

Establishing standardized workflows and SOPs is critical, but not ever easy to achieve. This is wherever automation systems play an important role, helping labs trim variability, amended consistency, and make much reliable information complete semipermanent experiments.

Live compartment imaging has go progressively important successful modern compartment biology. From your perspective, what makes continuous, non-disruptive monitoring truthful valuable compared pinch much accepted endpoint analysis?

Continuous, non-disruptive monitoring allows researchers to observe move compartment behaviour complete clip without disturbing nan civilization environment. Cells are highly delicate to conditions for illustration temperature, CO2, and humidity, truthful maintaining a unchangeable situation is essential.

In nan past, researchers typically relied connected endpoint analysis, watching only nan opening and last states of an experiment. Now, pinch continuous monitoring, they tin seizure nan full process, gaining overmuch deeper penetration into really cells behave and respond complete time.

The Celloger bid is designed for real-time monitoring wrong an incubator. For researchers caller to this area, really does this setup alteration really they tin observe and understand move cellular behavior?

By placing nan imaging strategy straight wrong nan incubator, researchers tin show cells continuously nether unchangeable conditions. This allows them to seizure real-time changes much people and consistently. While immoderate researchers whitethorn consciousness assured successful manual observation, our attraction is connected improving information credibility and repeatability alternatively than conscionable convenience.

Eliminating nan request to region samples reduces biology disruption and helps guarantee that results are much reliable and reproducible crossed experiments.

Image Credit: Curiosis Inc.

One of nan cardinal aspects that often interests researchers is exertion range. What kinds of studies is Celloger particularly well-suited for, and what tin scientists study from those experiments?

Celloger is designed for semipermanent compartment monitoring, truthful it is perfect for a wide scope of studies. These see proliferation, confluence, morphology, migration, stem compartment research, coiled treatment assays, and organoid growth.

Because nan strategy includes fluorescence functionality, researchers tin besides measurement fluorescence strength and way biologic processes successful much detail. Overall, it enables scientists to amended understand really cells respond and germinate complete clip nether different conditions.

When speaking to labs that are considering adopting a unrecorded compartment imaging system, what do they astir often underestimate astir nan effect it tin person connected research value aliases efficiency?

Many labs underestimate really overmuch automation tin amended reproducibility and efficiency. Some researchers judge that knowledgeable unit tin outperform automated systems, but nan existent worth lies successful consistency. It is not astir performing a task good once; it is astir achieving nan aforesaid value hundreds aliases thousands of times.

Automated imaging reduces manual intervention, minimizes variability, and yet increases nan credibility of experimental data.

Turning to nan CPX-α, your recently launched colony picking system, tin you explicate why colony picking is specified a captious measurement and wherever manual approaches typically autumn short?

Colony picking is simply a captious measurement because it straight affects downstream compartment statement quality. In applications for illustration antibody production, ensuring monoclonality is essential. Manual colony picking is often slow, labor-intensive, and inconsistent, which tin present variability into nan process.

Automated systems for illustration the CPX-α amended accuracy and efficiency, helping guarantee that nan correct colonies are selected and reducing nan consequence of errors that could effect downstream results.

Image Credit: Curiosis Inc.

Both nan Celloger and nan CPX-α look to support a broader push toward automation. How do you spot these kinds of devices changing nan equilibrium betwixt manual activity and data-driven decision-making successful nan lab?

We judge that galore laboratory workflows will displacement toward automation successful nan adjacent future. Automation systems, particularly erstwhile mixed pinch AI-driven study software, alteration faster processing, higher consistency, and improved information quality. This displacement allows researchers to attraction much connected interpreting results and making data-driven decisions alternatively than spending clip connected repetitive manual tasks.

When you speak pinch researchers, what do you deliberation is nan astir important misconception to reside astir automated imaging aliases automated colony picking?

A communal misconception is that automation is meant to switch quality expertise. In reality, it is astir enhancing consistency and reliability. I often show researchers that nan extremity is not to outperform a quality once, but to execute nan aforesaid high-quality consequence repeatedly. Automation ensures reproducibility astatine scale, which is captious for generating reliable technological data.

Since you precocious launched nan Celloger M22 and M26, could you supply an overview of these caller systems and really they heighten nan laboratory workforce?

The Celloger M22 and M26 build connected nan halfway capabilities of nan Celloger series, including brightfield imaging and two-color fluorescence. The main quality lies successful capacity. These systems tin scan aggregate plates simultaneously, either 2 aliases six plates, depending connected nan model, which makes them peculiarly well-suited for high-throughput screening environments specified arsenic supplier find and pharmaceutical investigation labs.

By expanding throughput while maintaining accordant imaging conditions, they thief labs grip larger workloads much efficiently without compromising information quality.

Looking ahead, what do you deliberation labs will request astir from nan adjacent procreation of ools?

Labs will request devices that merge much people into their regular workflows. Beyond method performance, easiness of use, standardization, and connectivity will go progressively important. Automation will proceed to play a awesome role, particularly erstwhile mixed pinch AI-driven analysis, enabling researchers to make larger datasets and extract much meaningful insights. The eventual extremity is to support amended subject by making experiments much consistent, efficient, and actionable.

About Dongmin Choi  

Dongmin Choi holds a Bachelor of Business Administration successful Marketing Management from De La Salle University and further studied trading astatine Hongik University. As Key Account Manager astatine Curiosis, he useful intimately pinch partners and researchers to support nan take of cell-based study technologies crossed laboratory and investigation environments.

About Curiosis

Curiosis Inc. develops, produces, and supplies laboratory instrumentality successful nan section of life science.

It provides solutions to amended nan ratio of cell-based investigation processes and intends to go a starring institution successful nan bioindustry.

Drawing connected halfway technologies successful mechanical engineering, biophysics, and electrical engineering, Curiosis intends to supply high-quality products to its customers and lend to a amended early for humanity.