Mediterranean Diet Benefits Identified By Sparc Levels

Researchers led by Drs. Jiqiu Wang and Guang Ning astatine Ruijin Hospital, Shanghai Jiao Tong University conducted a six-month randomized controlled feeding proceedings involving 235 Chinese adults pinch overweight aliases obesity and prediabetes. Participants were assigned to 1 of 3 calorie-restricted eating patterns: a Mediterranean diet, a accepted Jiangnan diet, aliases a power fare reflecting modern Shanghai dietary habits. All participants consumed controlled meals 5 days a week pinch a 25% caloric deficit.

Across nan trial, investigators measured circulating SPARC, a secreted macromolecule linked to adipose inflammation, astatine fasting, 1 hour, and 2 hours aft glucose intake. They recovered that only nan 1-hour post-glucose SPARC level astatine baseline, not fasting aliases 2-hour SPARC, predicted nan magnitude of metabolic betterment successful nan Mediterranean fare group. Individuals pinch little baseline SPARC-1H knowledgeable greater improvements successful insulin resistance, fasting insulin, and fasting glucose aft six months of dietary adherence nether caloric restriction. This predictive shape did not look successful nan Jiangnan aliases power fare groups, suggesting a diet-specific metabolic interaction.

Additional analyses showed that SPARC-1H was powerfully connected to changes successful circumstantial lipidomic profiles, peculiarly reductions successful respective plasmalogen type linked to red-meat intake and metabolic inflammation. These lipid shifts were characteristic of nan Mediterranean fare and whitethorn underlie why SPARC-1H functions arsenic a selective predictor for this dietary pattern.

The study besides revealed that different dietary patterns whitethorn require different predictive indicators. While SPARC-1H predicted metabolic improvements only successful nan Mediterranean fare group, fasting SPARC, alternatively than postprandial SPARC, was associated pinch improvements among participants pursuing nan accepted Jiangnan diet. This demonstrates that biomarkers should beryllium interpreted wrong circumstantial dietary contexts alternatively than applied universally.

The findings propose that a azygous post-meal biomarker could thief place individuals astir apt to execute important cardiometabolic use from a Mediterranean diet. The activity highlights a applicable way towards personalized dietary recommendations for group astatine consequence of metabolic diseases and underscores nan value of considering diet-specific physiology erstwhile processing precision nutrition tools.

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