Lifestyle Choices And Hormonal Imbalances Can Impact Men's Reproductive Health

A caller investigation insubstantial was published in Volume 12 of Oncoscience on September 30, 2025, titled "Lifestyle and hormonal factors affecting semen value and sperm DNA integrity: A cross-sectional study."

In this study, Saniya Imtiyaz Chamanmalik, Rajendra B. Nerli, and Pankaja Umarane from KLE Academy of Higher Education and Research and Dr. D. Y. Patil Medical College, Hospital and Research Centre discovered that immoderate manner choices and hormone changes tin importantly effect men's reproductive health. These findings are particularly important arsenic antheral infertility continues to summation successful India and astir nan world.

Infertility affects 1 successful six couples globally, pinch male-related factors contributing to astir half of each cases. This study addressed a awesome investigation spread successful India by examining really modifiable behaviors and hormone levels power semen value and nan familial integrity of sperm.

The researchers studied 278 Indian men aged 21 to 50. Nearly half of nan participants showed abnormal semen parameters. While older property did not trim semen measurement aliases motility, men complete 40 had higher levels of sperm DNA fragmentation, a cardinal marker of familial harm and reduced fertility potential.

The study recovered beardown associations betwixt mediocre manner choices and reduced sperm function. Tobacco and intoxicant usage importantly lowered sperm count, motility, and shape. Alcohol besides accrued sperm DNA fragmentation, which could negatively impact embryo development. Men exposed to precocious temperatures astatine activity had much DNA-damaged sperm, showing nan harmful effect of heat. Body weight besides played a awesome role: some underweight and overweight men had little semen value and higher DNA harm compared to men of normal weight.

 "Tobacco and intoxicant usage were powerfully associated pinch reduced sperm concentration, motility, and morphology (p < 0.001)."

In summation to manner factors, nan study besides highlighted nan domiciled of hormones successful antheral fertility. Men pinch debased testosterone aliases precocious prolactin levels had worse semen profiles. Notably, debased levels of anti-Müllerian hormone (AMH) were powerfully associated pinch higher sperm DNA fragmentation. Since AMH is produced by cells that support sperm development, it whitethorn service arsenic a useful caller marker of sperm health. Levels of different hormones for illustration FSH and LH remained stable, suggesting that targeted hormone testing could amended fertility assessment.

This study utilized nan astir caller World Health Organization guidelines for semen study and included precocious exams for sperm DNA fragmentation. The results propose that accepted semen testing whitethorn miss important indicators of fertility. Including manner information and hormone profiling could thief place reproductive problems earlier and lead to much effective treatments.

While nan study was constricted to a azygous halfway and did not see semipermanent follow-up, it provided valuable accusation astir nan increasing situation of antheral infertility successful India. The findings support nationalist wellness efforts to beforehand healthier lifestyles and regular hormone screening. Future investigation whitethorn thief find whether manner changes aliases hormone therapies tin repair sperm harm and amended fertility outcomes.